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1.When adherence is defined as greater than 4 hours of nightly use, 46 to 83% of patients with obstructive sleep apnea have been reported to be nonadherent to treatment. Weaver TE, Grunstein RR. Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proc Am Thorac Soc 2008; 5:173.
2.The objective mean use rate was 6.4 +- 1.7 h/night at 1 year follow-up in continuing users, with a regular use rate of 83%. Dieltjens M, Braem MJ, Vroegop AVMT, Wouters K, Verbraecken JA, De Backer WA, Van de Heyning PH, Vanderveken OM. Chest. 2013 Nov;144(5):1495-1502. doi: 10.1378/chest.13-0613.
3. Head-to-head trials confirm CPAP is superior in reducing OSA parameters on polysomnography; however, this greater efficacy does not necessarily translate into better health outcomes in clinical practice. Comparable effectiveness of OAm and CPAP has been attributed to higher reported nightly use of OAm, . Sutherland K, Vanderveken OM, Tsuda H, Marklund M, Gagnadoux F, Kushida CA, Cistulli PA, Oral Appliance Treatment for Obstructive Sleep Apnea: An Update. J Clin Sleep Med. 2014 Feb 15; 10(2): 215–227.
4. Tegelberg A, Wilhelmsson B, Erixon-Lindroth N, Lindström LH. Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea. Nat Sci Sleep. 2012 Aug 22;4:89-96. doi: 10.2147/NSS.S33849. PMID: 23620682; PMCID: PMC3630975.
5. Rangarajan H, Padmanabhan S, Ranganathan S, Kailasam V. Impact of oral appliance therapy on quality of life (QoL) in patients with obstructive sleep apnea – a systematic review and meta-analysis. Sleep Breath. 2022 Sep;26(3):983-996. doi: 10.1007/s11325-021-02483-0. Epub 2021 Sep 13. PMID: 34515959.
6. Iftikhar IH, Hays ER, Iverson MA, Magalang UJ, Maas AK. Effect of oral appliances on blood pressure in obstructive sleep apnea: a systematic review and meta-analysis. J Clin Sleep Med. 2013 Feb 1;9(2):165-74. doi: 10.5664/jcsm.2420. PMID: 23372472; PMCID: PMC3544387.
7. Lin, CC., Wang, HY., Chiu, CH. et al. Effect of oral appliance on endothelial function in sleep apnea. Clin Oral Invest 19, 437–444 (2015).
8. Anandam A, Patil M, Akinnusi M, Jaoude P, El-Solh AA. Cardiovascular mortality in obstructive sleep apnoea treated with continuous positive airway pressure or oral appliance: an observational study. Respirology. 2013 Nov;18(8):1184-90. doi: 10.1111/resp.12140. PMID: 23731062.
9. Marklund M, Verbraecken J, Randerath W. Non-CPAP therapies in obstructive sleep apnoea: mandibular advancement device therapy. Eur Respir J. 2012;39(5):1241–1247.
10. Sutherland K; Vanderveken OM; Tsuda H; Marklund M; Gagnadoux F; Kushida CA; Cistulli PA; on behalf of the ORANGE-Registry. Oral appliance treatment for obstructive sleep apnea: an update. J Clin Sleep Med 2014;10(2):215-227.
